Peer-reviewed veterinary case report
Gabapentin hybrid peptides and bioconjugates.
- Journal:
- Bioorganic & medicinal chemistry
- Year:
- 2014
- Authors:
- Lebedyeva, Iryna O et al.
- Affiliation:
- Department of Chemistry · United States
Abstract
Synthetic approaches to gabapentin bioconjugates that overcome the tendency of gabapentin to cyclize into its γ-lactam are studied. Gabapentin was converted by N-acylation at its N-terminus into di-, tri-, and tetrapeptides (L-Ala-Gbp, L-Val-Gbp, L-Ala-L-Phe-Gbp, Gly-L-Ala-β-Ala-Gbp). Carboxyl-activated Boc-protected gabapentin was used to N-, O-, and S-acylate small peptides and hormones to give conjugates that could also provide prodrugs containing conformationally constrained gabapentin units.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24468631/