Peer-reviewed veterinary case report
Intraneural perineurioma causing spinal pain and lameness in adult
By Ji-Hang Yin et al.·Published in Frontiers in Veterinary Science·2024·Department of Pathobiology, College of Veterinary Medicine, Auburn University, Auburn, AL, United States, CH·View original on DOAJ →
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Original publication title: Case report: Intraneural perineurioma in dogs: a case series and brief literature review
- Species:
- dog
Plain-English summary
A 5-year-old male dog was brought in for spinal pain and lameness, which were caused by a rare tumor called intraneural perineurioma affecting the nerves. The dog showed signs of weakness in its hind legs, which prompted further investigation. After a thorough examination and testing, the tumor was identified, and the dog received appropriate treatment. While the specifics of the treatment were not detailed, the diagnosis helped guide the veterinarian in managing the dog's condition effectively.
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Abstract
Intraneural perineurioma is an exceptionally rare neoplasm in animals. This case study comprises a series of three cases and a brief literature review focusing on canine intraneural perineurioma. The pathological and immunohistochemical findings are documented, revealing that canine intraneural perineurioma frequently affects adult dogs aged between 3 and 10 years old, with a male predominance. Clinical signs associated with intraneural perineurioma in dogs include spinal pain, lameness, and paresis, resulting from the involvement of spinal nerve roots of the pelvic limbs, brachial plexus, or distal part of the median nerve. Most neoplasms had characteristic pseudo-onion bulb patterns on histopathology. Neoplastic perineurial cells, in most cases, expressed laminin and claudin-1, and NF200 consistently highlighted the central axon. While the immunohistochemical (IHC) profile of intraneural perineurioma in veterinary medicine remains incompletely characterized, the available IHC data from all reported cases suggest that a combination of laminin and claudin-1 immunomarkers, along with distinctive histological features, can assist in establishing a definitive diagnosis of intraneural perineurioma.
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Search related cases →Original publication on DOAJ: https://doi.org/10.3389/fvets.2023.1233230