Peer-reviewed veterinary case report
COMT gene types linked to dog mammary tumor growth and outcome
By Canadas, Ana et al.·Published in Veterinary and comparative oncology·2018·Department of Pathology and Molecular Immunology·View original on PubMed →
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Original publication title: Catechol-o-methyltransferase genotypes are associated with progression and biological behaviour of canine mammary tumours.
- Species:
- dog
Plain-English summary
A group of 155 non-neutered female dogs with mammary tumors were studied to see how their genetic makeup might affect the tumors' behavior and progression. Researchers found that different genetic profiles (called genotypes) were linked to various tumor characteristics, such as how aggressive the cancer was and whether it spread to blood vessels. Understanding these genetic factors could help veterinarians tailor treatment plans and preventive measures for dogs with mammary tumors. This means that knowing a dog's specific genotype might improve their chances of better outcomes after surgery.
People also search for: dog mammary tumor treatment · canine cancer genetics · how to prevent mammary tumors in dogs
Abstract
The enzyme catechol-o-methyltransferase (COMT) is responsible for inactivation of catechol estrogens, which are well-recognized carcinogenic metabolites. Two single-nucleotide polymorphisms (SNPs) in canine COMT gene were previously associated with the age of onset of mammary tumours and with the clinical progression of the disease. However, no information is available regarding the impact of other known SNPs in COMT gene in canine mammary tumours. The aim of the present study is to evaluate the influence of COMT SNP in clinicopathological features and outcome of canine mammary tumours. A case series study was conducted involving 155 non-neutered bitches with mammary tumours submitted to follow-up for 24 months after surgery. Three genotypes were considered: Genotype 1 (rs853046495); Genotype 2 (rs23350589, rs23322686, rs23336579, and rs852564758); Genotype 3 (rs851328636 and rs853133060). Genotype 1 was associated to low degree of tubular differentiation. Genotype 2 was related to the development of intermediate/high-histological-grade carcinomas and to vascular invasion. Genotype 3 was associated to reduced nuclear pleomorphism and well-differentiated carcinomas. Data from the present investigation allowed the identification of COMT genetic profiles associated with pathological features of mammary tumours that constitute relevant prognostic factors. The assessment of the COMT genotypes may represent a helpful tool in the clinical management of canine mammary tumours, assisting in the selection of individualized preventive and therapeutic strategies, according to the animals' genetic profile.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30168237/