Peer-reviewed veterinary case report
Celastrol stops growth of canine mammary tumor cells by causing cell
By Ou, Guoxing et al.·Published in Frontiers in veterinary science·2021·College of Animal Science and Technology of Hainan University, China·View original on PubMed →
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Original publication title: Celastrol Inhibits Canine Mammary Tumor Cells by Inducing Apoptosisthe Caspase Pathway.
- Species:
- dog
Plain-English summary
A study found that celastrol, a natural extract, may help treat canine mammary tumors, which are a serious health threat for dogs. Researchers discovered that celastrol can slow down the growth of these tumor cells and reduce their ability to spread. It works by triggering cell death through specific pathways in the cells. While celastrol hasn't been used in clinical settings yet, it shows promise as a potential new treatment for dogs with mammary tumors.
People also search for: dog mammary tumor treatment · celastrol for canine cancer · canine breast cancer symptoms
Abstract
Canine mammary tumor is a serious disease threatening the health of dogs and can be used as a research model for human breast cancer. The study of canine mammary tumor has a role in improving the welfare of dogs. Most common canine mammary tumor chemotherapy drugs have limited effects and drug resistance. Celastrol is an extract of, which has a wide range of biological activities, including significant anti-tumor effects. At present, celastrol has not been used in the clinical treatment for canine mammary tumor. This study investigated the anti-tumor properties of celastrol throughassay of cell proliferation inhibition, cell colony, cell migration, and invasion; flow cytometry, qPCR, and Western Blot methods were used to explore the anti-tumor mechanism of celastrol. The results showed that celastrol can inhibit the proliferation of canine mammary tumor cells, and decrease the migration and invasion ability of canine mammary tumor cells. We also found that celastrol can upregulate Cleaved Caspase-3 and Cleaved Caspase-9 protein expression levels to promote cell apoptosis, and can regulate cell cycle-related proteins to induce cell cycle arrest. In summary, celastrol may inhibit canine mammary tumor cells through the Caspase pathway, providing a new direction for anti-canine mammary tumor drugs, and is expected to become a new anti-cancer drug for canine mammary tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35187141/