Peer-reviewed veterinary case report
Changes in immune cells in type 1 diabetic dogs on insulin injections
By Mori, Akihiro et al.·Published in The Journal of veterinary medical science·2008·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Changes in peripheral lymphocyte subsets in the type 1 diabetic dogs treated with insulin injections.
- Species:
- dog
Plain-English summary
A group of ten diabetic dogs receiving insulin injections had their immune system cells tested to see how their diabetes affected them. While the insulin helped manage their blood sugar levels, the dogs still had higher glucose levels compared to healthy dogs. The study found that certain immune cells were lower in the diabetic dogs, which could make them more vulnerable to infections. This suggests that even with treatment, diabetic dogs might have weakened immune systems and could be at risk for getting sick more easily.
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Abstract
Plasma metabolites and peripheral lymphocyte subsets were measured in ten diabetic and ten control dogs to investigate their significances as indicators to evaluate immune states in the diabetic dogs. Diabetic dogs were treated with insulin injections, however their plasma glucose and fructosamine concentrations were significantly higher than those of the controls. There were no significant differences in counts of total white blood cells (WBC) and lymphocyte CD8(+) cells (cytotoxic T cells) between the control and the diabetic dogs. In the diabetic dogs, the counts of CD3(+) (T cells), CD4(+) (Helper T cells) and CD21(+) (B cells) cells and the peripheral lymphocytes CD4/CD8 ratio were significantly lower than those in the control dogs. We confirmed abnormality of lymphocyte subsets in insulin treated diabetic dogs and it may relate to depression of immunocompetence and high susceptibility to common infectious diseases.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18319580/