Peer-reviewed veterinary case report
Amyloid deposits found in dog mammary tumors and their types
By Kato, Yuka et al.·Published in Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·2025·Tokyo University of Agriculture and Technology, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Characterization of amyloid deposits in canine mammary neoplasms.
- Species:
- dog
Plain-English summary
A study looked at 252 mammary tumors from 183 dogs to see how often amyloid deposits (abnormal protein clumps) were found in these tumors. They discovered that about 35% of the tumors had amyloid deposits, which were more common in higher-grade tumors. The findings suggest that older dogs and those with certain types of tumors are more likely to develop these deposits. Understanding this can help veterinarians better assess and treat dogs with mammary tumors.
People also search for: dog mammary tumor symptoms · canine amyloid deposits · treatment for dog breast cancer
Abstract
Mammary tumor-associated amyloidosis in dogs has been reported in several studies, but its incidence and predisposing conditions have not been investigated. We examined 252 mammary masses from 183 dogs to determine the prevalence of amyloid deposition and elucidate etiologic factors. Histologically, amyloid deposition was observed in 88 of 252 (35%) mammary masses. Amyloid deposition patterns were categorized into 3 types: stromal deposition (ST), deposition in corpora amylacea (CA), and precipitation within luminal secretions (PR). Of the 88 amyloid deposition cases, 49 were intra-tumoral, especially for ST-type amyloid deposits, which were all intra-tumoral. Immunohistochemistry and mass spectrometry revealed that ST-type amyloid deposits were positive for either serum amyloid A or α-S1-casein, depending on the sample; all CA- and PR-type amyloid deposits were positive for α-S1-casein. Statistically, intra-tumoral ST-type amyloid deposition was significantly more frequent in histologic grade II ( = 0.009) or III ( < 0.001) mammary tumors. In contrast, amyloid deposition in extra-tumoral tissues is significantly associated with aging ( = 0.002). Our findings suggest that the disruption of proteostasis in the canine mammary gland associated with tumorigenesis and aging can readily induce amyloid formation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40170364/