Peer-reviewed veterinary case report
Medical treatment results for dogs with unexplained kidney bleeding
By Kortum, A J et al.·Published in The Journal of small animal practice·2021·The Queen's Veterinary School Hospital, United Kingdom·View original on PubMed →
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Original publication title: Clinical findings and outcome following medical treatment in dogs with idiopathic renal haematuria: 41 cases (2001-2018).
- Species:
- dog
Plain-English summary
A group of dogs with unexplained blood in their urine, known as idiopathic renal haematuria, was treated at four veterinary centers in the UK. Most dogs had a good outcome, with a median survival time of nearly four years after diagnosis. Among those treated with medications like benazepril, about 42% showed complete resolution of the blood in their urine, while others had partial improvement. Only one dog was euthanized due to this condition, suggesting that the prognosis is generally favorable.
People also search for: dog blood in urine treatment · idiopathic renal haematuria in dogs · benazepril for dogs with blood in urine
Abstract
OBJECTIVES: To characterise and document the progression of idiopathic renal haematuria in a large cohort of medically managed UK dogs. MATERIALS AND METHODS: Retrospective study of 41 client-owned dogs with confirmed (n=14), or suspected (n=27) idiopathic renal haematuria from 4 UK-based referral centres. Clinical findings and outcomes of dogs (2001 to 2018) were determined from the review of medical records and telephone follow-up. RESULTS: Median survival time from diagnosis was long [1482 (152 to 1825) days] irrespective of treatment and clinical response. Only 1 case was euthanased due to idiopathic renal haematuria, and anaemia or azotaemia occurred infrequently. In total, 25 dogs received angiotensin-converting enzyme-inhibitor or angiotensin receptor blocker therapy, of which 23 received benazepril [0.44 (0.19 to 0.82) mg/kg/24 hours], two received enalapril (0.40 and 0.78 mg/kg/24 hours) and one received telmisartan (1 mg/kg/24 hours). In cases with follow-up urinalyses, complete resolution of haematuria was documented in eight of 19 (42%) dogs following angiotensin-converting enzyme-inhibitor/angiotensin receptor blocker treatment, with partial improvement in five of 19 (26%) and no improvement in six of 19 (31%). Conversely, of the two untreated dogs where outcome was available, one had partial improvement and the other had no improvement. CLINICAL SIGNIFICANCE: In this study, idiopathic renal haematuria was associated with a good prognosis and low complication rate. Resolution or improvement in haematuria occurred in both angiotensin-converting enzyme-inhibitor/angiotensin receptor blocker-treated and untreated dogs, indicating that further studies are required to evaluate the effectiveness and safety of these interventions.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34075582/