Peer-reviewed veterinary case report
Orbital hibernoma tumors in adult dogs aged 8-13 years
By Ravi, M et al.·Published in Veterinary pathology·2014·Alberta Agriculture and Rural Development, Canada·View original on PubMed →
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Original publication title: Clinical, morphologic, and immunohistochemical features of canine orbital hibernomas.
- Species:
- dog
Plain-English summary
A group of adult dogs, averaging around 10 years old, were found to have unusual soft lumps in their eye sockets, which turned out to be benign tumors made from brown fat called hibernomas. These tumors were not previously reported in dogs and were identified through a combination of clinical examination and advanced microscopic tests. The tumors were confirmed to have characteristics of brown fat cells, and some showed features that might link them to muscle cells. Fortunately, since these tumors are benign, they typically do not pose a serious health risk to the dogs.
People also search for: dog eye lump treatment · hibernoma in dogs · benign tumors in dogs · dog orbital tumor symptoms
Abstract
Hibernomas are uncommon benign tumors of brown fat that occur in humans and various animal species. They have not been observed in the orbit of dogs, humans, or other animals. Here we report clinical, light and electron microscopic, and immunohistochemical features of a series of 7 hibernomas arising in the orbital region of dogs. These neoplasms occurred in adult dogs with no breed predilection. The mean age of the affected dogs was 10.4 years (range, 8-13 years). All neoplasms presented as soft lobular masses composed of predominantly round or polygonal neoplastic cells with granular eosinophilic and vacuolated cytoplasm resembling adipocytes. The cytoplasm contained large numbers of pleomorphic mitochondria with dense matrices and indistinct cristae. Immunohistochemical evaluation confirmed positive labeling of neoplastic cells from all cases with uncoupling protein 1 (UCP-1) consistent with brown fat differentiation. Interestingly, rare neoplastic cells also expressed myogenin and myoD, possibly suggesting a common progenitor cell for neoplastic brown adipose and skeletal muscle cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23794150/