Peer-reviewed veterinary case report
High VEGF levels linked to malignant mammary tumors in dogs
By Kato, Yuka et al.·Published in The Journal of veterinary medical science·2007·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Clinical significance of circulating vascular endothelial growth factor in dogs with mammary gland tumors.
- Species:
- dog
Plain-English summary
A group of dogs with mammary gland tumors (MGT) had higher levels of a substance called vascular endothelial growth factor (VEGF) in their blood compared to healthy dogs. This increase in VEGF was even more pronounced in dogs with malignant tumors compared to those with benign ones. The study suggests that measuring VEGF levels could help veterinarians predict the outcome for dogs with MGT, especially in determining if the cancer has spread after surgery. While this research is promising, it's important for pet owners to discuss these findings with their veterinarian for personalized advice.
People also search for: dog mammary gland tumor prognosis · elevated VEGF in dogs · dog cancer treatment options
Abstract
Increase in circulating vascular endothelial growth factor (VEGF) is suggested as a prognostic indicator in human patients with malignant tumors. The purpose of this study was to evaluate the clinical significance of circulating VEGF in dogs with mammary gland tumors (MGT). Both plasma and serum VEGF were significantly higher in dogs with MGT when compared with those in the healthy dogs. In dogs with MGT, the plasma and serum VEGF of the malignant group increased significantly compared with those of the benign group. Additionally, there was a significant difference between the plasma and serum VEGF in the groups with postoperative metastasis and no metastasis. Circulating VEGF is expected to be clinically available for the determination of prognosis in canine MGT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17283406/