Peer-reviewed veterinary case report
Plasma mannose levels higher in diabetic dogs than healthy dogs
By Mori, A et al.·Published in Veterinary research communications·2009·Department of Veterinary Science, Japan·View original on PubMed →
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Original publication title: Clinical significance of plasma mannose concentrations in healthy and diabetic dogs.
- Species:
- dog
Plain-English summary
A study found that diabetic dogs had higher levels of mannose, a type of sugar, in their blood compared to healthy dogs. This increase in mannose was linked to higher blood glucose and insulin levels, suggesting that measuring mannose could help vets assess how well a diabetic dog is managing its insulin. After feeding, both healthy and diabetic dogs showed a decrease in mannose levels, but the response varied based on their insulin levels. This research suggests that testing for mannose could be a useful tool for diagnosing insulin resistance in diabetic dogs.
People also search for: diabetic dog symptoms · insulin resistance in dogs · mannose levels in diabetic dogs · blood sugar testing for dogs
Abstract
Circulating levels of monosaccharides can act as a reflection of systemic glucose/ energy metabolism. Characteristic changes observed in these levels can be seen in patients with diabetes and other metabolic disorders. There have been a few reports describing the significance of mannose metabolism as an energy source under physiological and pathological conditions. However, the relationship between circulating levels of mannose and the pathophysiology of diabetes mellitus are unknown in dogs. This study examined circulating levels of mannose between healthy control and diabetic dogs and evaluated the clinical significance of mannose levels in dogs. Diabetic dogs demonstrated a higher circulating level of mannose in comparison to normal healthy control dogs. Plasma mannose was positively correlated with plasma glucose and fructosamine, respectively. Interestingly, plasma mannose levels were affected by plasma insulin levels. In the context of feeding and glucose tolerance tests, plasma mannose levels responded to changes in circulating insulin levels. Circulating plasma mannose levels decreased after feeding in both control and diabetic animals in spite of observed insulin level differences. However, when glucose tolerance tests were given, a positive correlation between mannose levels and insulin levels was observed. Therefore, plasma mannose levels obtained via glucose tolerance testing may be used as a new diagnostic method for evaluating insulin resistance or deficiency in diabetic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19083115/