Peer-reviewed veterinary case report
Using cyclosporine and steroids to treat cats with pure red cell
By Viviano, Katrina R & Webb, Julie L·Published in Journal of Feline Medicine and Surgery·2011·Department of Medical Sciences, University of Wisconsin-Madison, School of Veterinary Medicine, 2015 Linden Dr, Madison, WI 53711, USA, United States·View original on Crossref →
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Original publication title: Clinical Use of Cyclosporine as an Adjunctive Therapy in the Management of Feline Idiopathic Pure Red Cell Aplasia
- Species:
- cat
Plain-English summary
A group of 10 cats with a serious blood condition called idiopathic pure red cell aplasia (PRCA) were treated with a combination of steroids and cyclosporine, an immunosuppressive medication. Out of the 8 cats that were monitored, they achieved remission for an average of about 31 days and maintained it for up to 406 days. While some cats were able to stop treatment, most needed to stay on a low dose of medication to prevent relapse. The cats generally tolerated the treatment well, with any side effects manageable through dose adjustments.
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Abstract
The clinical use of cyclosporine is described in a group of client-owned cats diagnosed with idiopathic pure red cell aplasia (PRCA). All 10 cats were treated with combinations of glucocorticoids and cyclosporine. Of the 10 cats, the eight for which follow-up data was available achieved and maintained remission for a median of 31 and 406 days, respectively. Therapy was reduced or discontinued in 7/8 cats; 2/7 maintained remission off therapy and 5/7 cats relapsed. Remission was reinduced in four cats, with 3/4 cats maintained long-term on low dose therapy. Adverse effects associated with cyclosporine therapy were responsive to dose reduction or drug withdrawal. Feline idiopathic PRCA was responsive to combination immunosuppressive therapy with glucocorticoids and cyclosporine. Relapse was common, particularly after drug discontinuation; therefore, most cats required maintenance long-term low dose therapy.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2011.07.007