Peer-reviewed veterinary case report
Dog with rare ovarian tumor and two different mammary cancers
By Golchin, Diba et al.·Published in Veterinary medicine and science·2025·Department of Pathology and Clinical Pathology·View original on PubMed →
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Original publication title: Co-Occurrence of Ovarian Dysgerminoma-Inducing Gonadoblastoma and Two Distinct Mammary Carcinomas in a Dog: A Case Report and Review of the Literature.
- Species:
- dog
Plain-English summary
A 12-year-old female Spitz was diagnosed with two types of breast cancer and a rare ovarian tumor called gonadoblastoma, which can occur in dogs with certain genetic conditions. Despite appearing normal, she had these serious tumors that required careful examination. The veterinary team used various tests to identify the tumors and their characteristics. Unfortunately, the outcome of her treatment is not detailed, but this case highlights the complexity of diagnosing and treating unusual tumors in pets.
People also search for: dog breast cancer treatment · ovarian tumor in dogs · Spitz cancer symptoms
Abstract
Gonadoblastoma (GB) is an extremely rare mixed gonadal neoplasm, encountered in animals as well as humans. The tumour is typically reported in dysgenetic gonads of those suffering from disorders of sex development and bearing the Y chromosome. Here we highlight the first report of the co-occurrence of an ovarian dysgerminoma-inducing GB and anaplastic and complex carcinomas of distinct mammary glands in a phenotypically normal 12-year-old intact female Spitz lacking the Y chromosome. Germ cells of GB and dysgerminoma were negative for c-kit but immunolabelled with SALL4, OCT-4, and E-cadherin and aberrantly expressed WT-1. Sex cord-stromal cells were immunoreactive for α-inhibin, cytokeratin AE1/AE3, and WT-1. Diffuse vimentin immunostaining was observed, while all cells were negative for high molecular weight cytokeratins. The Ki67 index was 30%. We describe the histopathological and immunohistochemical features of the index case and the polymerase chain reaction analysis of the amelogenin (AMEL) gene and provide a review of the literature. The mechanism of GB development may vary in patients with normal karyotypes and dysgenetic individuals. The WT-1 gene mutation may also play a role in the development of GB in the present case.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40552403/