Peer-reviewed veterinary case report
Colistin-glycopeptide combinations against multidrug-resistantin a mouse model of pneumonia.
- Journal:
- Future microbiology
- Year:
- 2019
- Authors:
- Sanderink, Diane et al.
- Affiliation:
- CRCINA · France
Abstract
To assess the effect of colistin-glycopeptide combination against a multidrug-resistant strain of. We usedprocedures (Etest method, checkerboard test and kill-time assays) and a mouse model of a carbapenem-resistantpneumonia.The colistin-teicoplanin combination allowed a 74% increase of the survival in the mouse model within the 4 days following bacterial inoculation as compared with saline or colistin alone (p = 0.06). Concurrently, the colistin-vancomycin combination presented a similar efficacy as compared with saline or colistin alone in the mouse model.According to those preliminary results, using the colistin-teicoplanin combination in therapeutic deadlocks encountered in certain multiresistantpneumonia could be envisaged if the results are confirmed.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31172805/