Peer-reviewed veterinary case report
In vitro and in vivo activities of tigecycline-colistin combination therapies against carbapenem-resistant Enterobacteriaceae.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2014
- Authors:
- Betts, Jonathan W et al.
- Affiliation:
- Blizard Institute · United Kingdom
Abstract
We assessed the activity of tigecycline (TGC) combined with colistin (COL) against carbapenem-resistant enterobacteria. Synergy occurred in vitro against the majority of isolates, with the exception of Serratia marcescens. In a simple animal model (Galleria mellonella), TGC-COL was superior (P < 0.01) in treating Escherichia coli, Klebsiella pneumoniae, and Enterobacter infections, including those with TGC-COL resistance. Clinical studies are needed to determine whether TGC-COL regimens may be a viable option.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/24687491/