Peer-reviewed veterinary case report
Blood and tissue tests for canine mammary tumors
By Yuying Fan et al.·Published in Scientific Reports·2021·Department of Veterinary Clinic, College of Veterinary Medicine, Northeast Agricultural University, GB·View original on DOAJ →
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Original publication title: Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients
- Species:
- dog
Plain-English summary
A study looked at dogs with mammary gland tumors to see if certain blood and tissue markers could help diagnose the condition. The markers CA15-3, CEA, and SF were found to be higher in dogs with malignant tumors compared to those with benign tumors or healthy dogs. The combination of these markers improved the ability to detect malignant tumors, with an accuracy of about 80%. This means that using these tests together could help veterinarians better identify serious cases of mammary tumors in dogs, potentially leading to earlier treatment.
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Abstract
Abstract The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.
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Search related cases →Original publication on DOAJ: https://doi.org/10.1038/s41598-021-85029-4