Peer-reviewed veterinary case report
Blood tests for markers CA15-3, CEA, and SF in dogs with mammary
By Fan, Yuying et al.·Published in Scientific reports·2021·Department of Veterinary Clinic, China·View original on PubMed →
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Original publication title: Combined detection of CA15-3, CEA, and SF in serum and tissue of canine mammary gland tumor patients.
- Species:
- dog
Plain-English summary
A group of dogs with mammary gland tumors had their blood and tissue tested for specific markers (CA15-3, CEA, and SF) to help diagnose the type of tumor. The study found that dogs with malignant tumors had higher levels of these markers compared to those with benign tumors or healthy dogs. Among the markers, SF was the most sensitive, while CA15-3 was the most specific for identifying malignant tumors. Using all three markers together improved the ability to detect serious tumors, which could help veterinarians make better treatment decisions.
People also search for: dog mammary tumor symptoms · CA15-3 test for dogs · canine mammary cancer treatment
Abstract
The purpose of this study is to evaluate the levels and clinical diagnosis value of CA15-3, CEA, and SF in canine mammary gland tumors (CMGTs). In this study, the levels of tissues/serum CA15-3, CEA, and SF in 178 CMGT patients or healthy dogs were determined by ELISA and qRT-PCR assay. CA15-3, CEA, and SF levels of the malignant tumor group were significantly higher than that of the benign tumor group and the healthy control group. In the malignant tumor group, CA15-3 held a sensitivity of 51.8%, a specificity of 93.9%, and an accuracy of 76.8%. The sensitivity, specificity, and accuracy of CEA were 44.6%, 84.1%, and 68.1% respectively. SF held a sensitivity of 62.5%, a specificity of 85.4%, and an accuracy of 76.1%. SF showed the highest sensitivity and CA15-3 showed the highest specificity. The sensitivity, specificity, and accuracy of the combined detection of the three biomarkers in malignant tumor groups were 80.4%, 78.0%, and 80.0%, respectively, therefore combined detection increased sensitivity and accuracy but decreased specificity. In conclusion, the combined detection of serum/tissue markers CA15-3, CEA, and SF may improve the detection sensitivity of CMGTs, providing reference value for clinical application.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33758208/