Peer-reviewed veterinary case report
Blood test changes in 312 diabetic dogs and related diseases
By Slead, Tanner S et al.·Published in Journal of the American Animal Hospital Association·2022·From the Department of Veterinary Clinical Sciences·View original on PubMed →
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Original publication title: Complete Blood Counts and Blood Smear Analyses in 312 Diabetic Dogs (2007-2017).
- Species:
- dog
Plain-English summary
A group of 312 diabetic dogs was examined to see how their blood counts and blood cell shapes related to other health issues. The study found that diabetic dogs often had specific blood cell changes, like high-grade codocytosis (abnormal red blood cells), which were linked to lower red blood cell counts and higher white blood cell counts. These changes were also more common in dogs that developed diabetic ketoacidosis, a serious condition. The findings suggest that checking blood smears should be a regular part of assessing diabetic dogs to catch potential complications early.
People also search for: diabetic dog blood test results · dog diabetes complications · high white blood cell count in dogs · diabetic ketoacidosis in dogs · blood smear analysis for dogs
Abstract
Diabetes mellitus is a common endocrinopathy in dogs that has been associated with various biochemical changes and comorbid diseases, but hematologic abnormalities have been rarely reported. The aim of this retrospective study was to evaluate complete blood count and blood smear alterations and to describe their relationship with, and incidence of comorbid diseases in, diabetic dogs. Three-hundred twelve diabetic dogs, 286 dogs diagnosed with systemic, nondiabetic illnesses, and 506 healthy dogs were identified during the study period. Groups were compared using contingency tables and logistic regression. Associations between statistically significant complete blood count and blood smear alterations and comorbidities were evaluated using multivariable analysis. High-grade codocytosis and anisocytosis were identified more frequently in diabetic dogs, whereas high-grade reactive lymphocytosis and keratocytosis were identified less frequently (P < .001). Diabetic dogs with high-grade codocytosis had lower red blood cell, hemoglobin, hematocrit and higher white blood cell counts (P < .001). Diabetic ketoacidosis was diagnosed more frequently in diabetic dogs with high-grade codocytosis when compared with those with low-grade codocytosis (P < .001) or when compared with any other cell morphologic alterations. This study suggests that blood smear analysis should be a routine part of the evaluation of diabetic dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35793489/