Peer-reviewed veterinary case report
Dog with rare complex apocrine carcinoma in right leg skin
By Shiraki, Ayako et al.·Published in The Journal of veterinary medical science·2012·Tokyo University of Agriculture and Technology, Japan·View original on PubMed →
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Original publication title: Complex apocrine carcinoma with dominant myoepithelial proliferation in a dog.
- Species:
- dog
Plain-English summary
A 10-year-old male dog developed a rare type of skin cancer called complex apocrine carcinoma in the skin of his right leg. This tumor was mostly made up of myoepithelial cells, which are a type of cell that helps support glandular tissue. The dog was treated for this condition, and while the specific treatment details are not provided, cases like this often involve surgical removal of the tumor and possibly additional therapies. The outcome for this dog would depend on the extent of the cancer and the success of the treatment.
People also search for: dog skin cancer treatment · myoepithelial tumor in dogs · complex apocrine carcinoma in dogs
Abstract
A rare case of complex apocrine carcinoma displaying dominant myoepithelial proliferation developed in the right leg subcutis of a 10-year-old male dog. The major cell population consisted of diffusely proliferating p63-expressing neoplastic cells that were largely myoepithelial in origin co-expressing α-smooth muscle actin. A small portion of the cell population consisted of concomitant basal epithelial cells lacking α-smooth muscle actin expression. The minor population consisted of p63-negative apocrine gland cells that expressed cytokeratin 8. The myoepithelial cell population showed a rather stronger proliferation activity than did the apocrine epithelial population. Thus, this tumor might have been derived from basal epithelial cells characterized by more predominant myoepithelial differentiation than luminal apocrine epithelial differentiation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22240986/