Peer-reviewed veterinary case report
Curcuminoid supplements effects on dogs with diabetes
By Suemanotham, Namphung et al.·Published in Frontiers in veterinary science·2022·Department of Clinical Sciences and Public Health·View original on PubMed →
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Original publication title: Curcuminoid supplementation in canine diabetic mellitus and its complications using proteomic analysis.
- Species:
- dog
Plain-English summary
A group of dogs with diabetes was given a daily supplement of curcumin, a natural anti-inflammatory and antioxidant, for six months to see if it could help manage their condition. The dogs showed reduced oxidative stress, which is a harmful condition often linked to diabetes, and there were no negative effects on their health. While the supplement didn't change certain inflammatory markers, it appeared to improve insulin sensitivity and may help prevent heart-related issues. Overall, curcumin could be a helpful addition to standard diabetes treatment for dogs.
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Abstract
INTRODUCTION: Inflammation and oxidative stress contribute to diabetes pathogenesis and consequences. Therapeutic approaches for canine diabetes remain a challenge. Curcumin has anti-inflammatory and anti-oxidative effects and is beneficial for humans with diabetes mellitus (DM); however, data on its impact on canine diabetes is limited. This study aimed to evaluate the potential for causing adverse effects, anti-inflammatory effects, anti-oxidative effects and proteomic patterns of curcuminoid supplementation on canine DM. METHODS: Altogether, 18 dogs were divided into two groups: DM (= 6) and healthy (= 12). Curcuminoid 250 mg was given to the DM group orally daily for 180 days. Blood and urine sample collection for hematological parameters, blood biochemistry, urinalysis, oxidative stress parameters, inflammatory markers and proteomics were performed every 6 weeks. RESULTS AND DISCUSSION: Curcuminoid supplementation with standard therapy significantly decreased oxidative stress with the increased glutathione/oxidized glutathione ratio, but cytokine levels were unaffected. According to the proteomic analysis, curcuminoid altered the expression of alpha-2-HS-glycoprotein, transthyretin, apolipoprotein A-I and apolipoprotein A-IV, suggesting that curcuminoid improves insulin sensitivity and reduces cardiovascular complications. No negative impact on clinical symptoms, kidneys or liver markers was identified. This study proposed that curcuminoids might be used as a targeted antioxidant strategy as an adjunctive treatment to minimize diabetes complications in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/36619946/