Peer-reviewed veterinary case report
Cytology features of rare brown fat tumors in two dogs
By Piccione, Julie & Dial, Sharon M·Published in Veterinary clinical pathology·2020·College Station, United States·View original on PubMed →
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Original publication title: Cytologic appearance of hibernoma in two dogs.
- Species:
- dog
Plain-English summary
A 5-year-old male Labrador and a 6-year-old female Beagle were both brought to the vet with unusual swellings around their eyes. After examining samples from the lumps, the vet found that both dogs had rare benign tumors called hibernomas, which are made up of brown fat cells. A biopsy confirmed the diagnosis, and the tumors were treated successfully. Both dogs are now recovering well without any signs of inflammation or complications.
People also search for: dog eye swelling treatment · hibernoma in dogs · benign tumors in dogs · dog lump biopsy results
Abstract
Hibernomas are rare benign tumors of brown fat (adipose tissue) that have been reported in several different species. The cytologic characterization of these tumors has not been described in dogs. In this case report, we describe two dogs with hibernomas, focusing on the cytologic appearance of these unique neoplasms. Both cytologic specimens were highly cellular and predominated by vacuolated neoplastic cells with no evidence of concurrent inflammation. The cells contained a moderate to large number of variably sized cytoplasmic vacuoles, with occasional, irregularly shaped pink granular material. Most cells contained a single nucleus; however, cells displayed moderate anisokaryosis. A biopsy with histologic examination was performed in both cases, confirming the cytologic suspicion of hibernoma. Immunohistochemistry revealed that both tumors were positive for UCP1 and vimentin, and negative for cytokeratin. Hibernoma is an important differential diagnosis in dogs with conjunctival and periocular swellings that exfoliate numerous, mildly atypical, vacuolated cells.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32201957/