Peer-reviewed veterinary case report
Diabetes does not change muscle relaxant effects of atracurium in dogs
By Leece, Elizabeth A & Clark, Louise·Published in Veterinary anaesthesia and analgesia·2017·Centre for Small Animal Studies, United Kingdom·View original on PubMed →
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Original publication title: Diabetes mellitus does not affect the neuromuscular blocking action of atracurium in dogs.
- Species:
- dog
Plain-English summary
A study looked at how a muscle relaxant called atracurium worked in both diabetic and non-diabetic dogs during surgery. The researchers found that the length of time atracurium was effective was about the same for both groups, even though the diabetic dogs were older and had slightly different heart rates and body temperatures. This means that having diabetes didn't change how well atracurium worked for muscle relaxation during anesthesia. Both groups of dogs responded well to the treatment.
People also search for: dog diabetes surgery · atracurium muscle relaxant for dogs · anesthesia effects on diabetic dogs
Abstract
OBJECTIVE: To compare the duration of action of atracurium in diabetic and nondiabetic dogs. STUDY DESIGN: Prospective, blinded, clinical study. ANIMALS: A total of 26 diabetic and 29 nondiabetic dogs. METHODS: Following preanaesthetic medication and intravenous (IV) propofol induction, anaesthesia was maintained with isoflurane in oxygen. Atracurium 0.2 mg kgIV was administered to provide neuromuscular blockade (NMB) and the responses (twitches; T) to train-of-four nerve stimulation were recorded by palpation and electromyography (EMG). Time to onset of NMB (from atracurium administration to loss of T4 by EMG), duration of NMB (to return of T1 by EMG) and also times to loss and return of T2-T4 were recorded. Heart rate (HR), mean arterial pressure, end-tidal isoflurane (Fe'Iso), end-tidal COconcentrations and oesophageal temperature were recorded at onset of NMB and when T1returned. Groups were compared using t tests and Mann-Whitney U tests (p<0.05). RESULTS: Diabetic dogs were older (9.9±0.3 compared with 6.8±0.7 years, p=0.0003). Group parameters were similar at onset and offset of NMB apart from HR at offset, which was higher for diabetics compared to nondiabetics (114±4 compared with 100±3 beats minute, respectively, p=0.004), Fe'Iso was higher in the diabetic group at onset (1.3±0.03% compared with 1.2±0.04%, p=0.026) and offset (1.4±0.03% compared with 1.3±0.03%, p=0.007), and temperature was higher for diabetics at onset (37.5±0.1 °C compared with 37.0±0.2 °C, p=0.012) and offset (37.5±0.1 °C compared with 36.9±0.2 °C, p=0.004). The duration of action of atracuriumand atracuriumwere similar for both groupsCONCLUSIONS AND CLINICAL RELEVANCE: The duration of action of atracurium was similar in diabetic and nondiabetic dogs as indicated by tactile and EMG monitoring.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28863931/