Peer-reviewed veterinary case report
mTOR signaling pathway active in dog skin papillomas
By Sanz Ressel, Berenice L et al.·Published in Veterinary and comparative oncology·2019·Laboratorio de Histologí·View original on PubMed →
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Original publication title: Dysregulated expression of the key effectors of the mammalian target of rapamycin signalling pathway in cutaneous papillomas of dogs.
- Species:
- dog
Plain-English summary
A study looked at skin growths called cutaneous papillomas (CP) in dogs, which are common skin tumors. Researchers found that a specific signaling pathway in the body, known as the PI3K/Akt/mTOR pathway, is often overactive in these tumors. This suggests that targeting this pathway could be a potential treatment option for dogs with CP. If your dog has skin growths, it may be worth discussing this information with your veterinarian to explore possible treatments.
People also search for: dog skin tumors treatment · cutaneous papillomas in dogs · dog skin growths causes
Abstract
Cutaneous papillomas (CP) are one of the most common skin neoplasms in dogs. Different murine models have shown that persistent activation of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR) pathway has a central role in the development and progression of CP. The purpose of this study were to evaluate the immunohistochemical expression pattern of two key molecules involved in the PI3K/Akt/mTOR signalling pathway, pAkt, and pS6, on 36 canine specimens of CP using a tissue microarray. The results show that the PI3K/Akt/mTOR signalling pathway is persistently activated in CP of dogs, pointing to this pathway as a potential therapeutic target.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31222908/