Peer-reviewed veterinary case report
Ovariohysterectomy during benign mammary tumor removal in female dogs
By Kristiansen, V M et al.·Published in Journal of veterinary internal medicine·2013·Department of Companion Animal Clinical Sciences·View original on PubMed →
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Original publication title: Effect of ovariohysterectomy at the time of tumor removal in dogs with benign mammary tumors and hyperplastic lesions: a randomized controlled clinical trial.
- Species:
- dog
Plain-English summary
An 8-year-old female dog with a nonmalignant mammary tumor was treated with surgery to remove the tumor, and some dogs also underwent ovariohysterectomy (OHE), which is the removal of the ovaries and uterus. The study found that dogs that had OHE at the same time as their tumor removal were about half as likely to develop new mammary tumors compared to those that did not have the surgery. While the OHE did not significantly change survival rates, it did help prevent the growth of new tumors. This suggests that OHE could be a beneficial option for dogs with these types of tumors.
People also search for: dog mammary tumor treatment · ovariohysterectomy benefits for dogs · how to prevent dog tumors
Abstract
BACKGROUND: Nonmalignant mammary tumors (NMT) are common in intact female dogs. Little is known about the clinical significance of these tumors, and the effect of ovariohysterectomy (OHE) on their development. HYPOTHESIS: Ovarian hormone ablation through OHE decreases the risk of new tumors and thereby improves long-term prognosis for dogs with NMT. ANIMALS: Eighty-four sexually intact bitches with NMT. METHODS: Dogs were allocated to undergo OHE (n = 42) or not (n = 42) at the time of NMT removal in a randomized clinical trial. Tumor diagnosis was confirmed histologically in all subjects. Information about new tumor development was collected via follow-up phone calls and recheck examinations. Separate survival analyses were performed with the endpoints new tumor development and death. Cause of death was classified as related or unrelated to mammary tumor. In addition to OHE status, the influence of age, body weight, breed, tumor size, tumor number, tumor duration, type of surgery, and tumor histology was investigated. RESULTS: New mammary tumor(s) developed in 27 of 42 (64%) intact dogs and 15 of 42 (36%) ovariohysterectomized dogs (hazard ratio 0.47, P = .022). Nine of the 42 dogs (21%) which developed new tumors were euthanized because of mammary tumor. Survival was not significantly different between the 2 treatment groups. In the intact group, nine dogs subsequently developed ovarian-uterine diseases. CONCLUSION: Ovariohysterectomy performed at the time of mammary tumor excision reduced the risk of new tumors by about 50% among dogs with NMT. Survival was not significantly affected. Adjuvant OHE should be considered in adult dogs with mammary tumors.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23701181/