Peer-reviewed veterinary case report
SGLT2 inhibitor DWP16001 added to insulin helps control diabetes
By An, Ju-Hyun et al.·Published in Veterinary medicine and science·2024·Department of Veterinary Emergency and Critical Care Medicine and Institute of Veterinary Science, South Korea·View original on PubMed →
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Original publication title: Effect of the sodium-glucose cotransporter-2 inhibitor, DWP16001, as an add-on therapy to insulin for diabetic dogs: A pilot study.
- Species:
- dog
Plain-English summary
Nineteen diabetic dogs receiving insulin were given a new medication called DWP16001 to see if it could help control their blood sugar levels better. The dogs were split into two groups, with one group getting the medication every day and the other every three days. After 12 months, both groups showed lower blood sugar levels and needed less insulin without any harmful side effects. This suggests that DWP16001 could be a safe and effective add-on treatment for diabetic dogs already on insulin.
People also search for: diabetic dog treatment · insulin for dogs · DWP16001 for diabetic dogs · blood sugar control in dogs · side effects of diabetes medication for dogs
Abstract
BACKGROUND: Sodium-glucose cotransporter-2 (SGLT2) inhibitors are a novel class of anti-hyperglycaemic agents. OBJECTIVE: This study aimed to evaluate the safety and the adjuvant glycaemic control effect of an SGLT2 inhibitor, DWP16001, in diabetic dogs receiving insulin treatment. METHODS: Nineteen diabetic dogs receiving insulin treatment (NPH, porcine lente and glargine insulin) were divided into two groups according to dosing frequency: DWP TOD group (n = 10) and DWP SID group (n = 9). In the DWP TOD group, 0.025 mg/kg of DWP16001 was administered once every 3 days, whereas, in the DWP SID group, 0.025 mg/kg of DWP16001 was administered once a day. Food intake was maintained during the trial period. Hypoglycaemia, ketoacidosis or unexpected life-threatening reactions were assessed as adverse effects before and after DWP16001 administration. We compared insulin requirement reduction and blood glucose level control between two groups. RESULTS: No specific adverse effects were observed during the clinical trial, and haematological parameter remained unchanged. Moreover, the fasting glucose levels and daily insulin dose in the DWP TOD group were lower than the pre-administration values, but not significantly different for 8 weeks. Systolic blood pressure, fructosamine and insulin dose decreased significantly in the DWP SID group compared to the DWP TOD group at 8 weeks (p < 0.05) without affecting food consumption. Among these patients, 10 patients were monitored while receiving DWP16001 for 12 months (DWP TOD group n = 5, DWP SID group n = 5). The fasting glucose and fructosamine levels and daily insulin dose were reduced in both groups at 12 months compared with those before receiving DWP16001. CONCLUSION: When DWP16001, an SGLT2 inhibitor, was supplied to dogs with type 1 diabetes, no adverse effects were observed, and it was confirmed that the administered insulin dose can be reduced in controlling blood glucose.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38686463/