Peer-reviewed veterinary case report
COX-2 inhibitor celecoxib helps dogs with glucagon delayed stomach
By Xu, J & Chen, J D Z·Published in Neurogastroenterology and motility·2007·University of Texas Medical Branch, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Effects of cyclooxygenase-2 inhibitor on glucagon-induced delayed gastric emptying and gastric dysrhythmia in dogs.
- Species:
- dog
Plain-English summary
A group of healthy female dogs experienced delayed gastric emptying and abnormal stomach rhythms after receiving glucagon, a hormone that can affect digestion. Researchers tested a medication called celecoxib, which is a COX-2 inhibitor, to see if it could help. They found that celecoxib improved the delayed gastric emptying caused by glucagon, but it did not fix the abnormal stomach rhythms. This suggests that celecoxib might be a helpful treatment for dogs with similar digestive issues, especially those related to diabetes.
People also search for: dog delayed gastric emptying treatment · glucagon effects on dog digestion · celecoxib for dog stomach problems
Abstract
The objective of this study was to investigate the effects of cyclooxygenase-2 (COX-2) inhibitor (celecoxib) on delayed gastric emptying and gastric dysrhythmia induced by glucagon. The study was performed in six healthy female dogs implanted with four pairs of gastric serosal electrodes, and a duodenal fistula for the assessment of gastric emptying. Each dog was studied in three randomized sessions: control, glucagon and COX-2 inhibitor (celecoxib). Gastric emptying was assessed every 15 min via a duodenal cannula by calculating the amount of collected phenol red which mixed with the test meal and gastric slow waves were recorded at the same time. We found that: (i) glucagon significantly and substantially decreased gastric emptying of liquids (P < 0.001, anova), increased blood glucose (BG) levels, and induced gastric dysrhythmias. The delayed gastric emptying was correlated with the BG level (R = -0.77, P < 0.001) and (ii) celecoxib improved glucagon-induced delayed gastric emptying at 30, 45, 60 and 75 min after feeding. Celecoxib did not blocked dysrhythmic action of glucagon (P > 0.05, anova). In conclusion, glucagon induces delayed gastric emptying partially via COX-2-derived prostaglandins. However, COX-2-derived prostaglandins are not involved in glucagon-evoked gastric dysrhythmia. Selective COX-2 inhibitors may provide a possible therapeutic option for diabetic gastroparesis.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17244169/