Peer-reviewed veterinary case report
Sibutramine speeds up stomach emptying in dogs after eating
By Xu, Junying & Dz Chen, Jiande·Published in Digestive diseases and sciences·2008·University of Texas Medical Branch, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Effects of sibutramine on gastric emptying, intestinal motility and rectal tone in dogs.
- Species:
- dog
Plain-English summary
A group of 14 dogs was studied to see how a medication called sibutramine affected their stomach and bowel movements. The dogs received sibutramine before meals, which helped their stomachs empty liquids faster but slowed down contractions in the small intestine. This means that while the dogs' stomachs processed liquids more quickly, their intestines moved food along more slowly. The results suggest that sibutramine could help with weight loss in dogs by changing how their digestive systems work.
People also search for: dog stomach emptying medication · sibutramine for dog weight loss · dog bowel movement issues
Abstract
The aim of this study was to evaluate the effects of sibutramine on gastric emptying, small-bowel contractions, rectal tone and compliance, and gastrointestinal myoelectrical activity. The study was performed in 14 dogs. It was composed of three separate experiments: gastric emptying of liquids and gastrointestinal slow waves; small-bowel contractions; and rectal tone and rectal compliance. Each experiment included two sessions: a control session and a treatment session with sibutramine (5 mg/kg orally) administrated 2 h before the study. Sibutramine significantly accelerated liquid gastric emptying at 75 and 90 min after the meal but did not alter gastrointestinal slow waves. Gastric emptying at 75 and 90 min was 61.42 +/- 7.71 and 66.32 +/- 7.67% in the control session, and increased to 71.27 +/- 5.14 and 75.93 +/- 5.29% in the session with sibutramine (p < 0.05, vs. control). Sibutramine significantly inhibited postprandial small-bowel contractions. Sibutramine did not alter the rectal tone, but significantly increased rectal compliance. Sibutramine accelerates gastric emptying of liquids but inhibits small-bowel contractions. These findings suggest the peripheral mechanisms of sibutramine in reducing food intake and causing weight loss in obesity patients.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17510801/