Peer-reviewed veterinary case report
Maropitant injection helps stop vomiting from cisplatin chemo in dogs
By Vail, D. M. et al.·Published in Veterinary and Comparative Oncology·2007·View original on Crossref →
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Original publication title: Efficacy of injectable maropitant (Cerenia™) in a randomized clinical trial for prevention and treatment of cisplatin‐induced emesis in dogs presented as veterinary patients
- Species:
- dog
Plain-English summary
A group of dogs undergoing chemotherapy for cancer experienced nausea and vomiting due to a drug called cisplatin. Researchers tested a medication called maropitant (Cerenia™) to see if it could help prevent or treat this vomiting. The results showed that dogs given maropitant before or after receiving cisplatin had significantly fewer vomiting episodes compared to those who did not receive the medication. In fact, nearly all dogs that received maropitant before treatment did not vomit at all. Maropitant was found to be safe and very effective for these dogs.
People also search for: dog vomiting after chemotherapy · Cerenia for dogs nausea · cisplatin side effects in dogs
Abstract
AbstractChemotherapy‐induced nausea and vomiting (CINV) is a common side‐effect of cisplatin therapy. Maropitant (Cerenia™), a novel neurokinin‐1 receptor antagonist, was evaluated for prevention and treatment of cisplatin‐induced emesis in tumour‐bearing dogs. Dogs (n= 122) were randomly allocated to three treatment groups: T01, placebo before and after cisplatin; T02, placebo before and maropitant after cisplatin; or T03, maropitant before and placebo after cisplatin. Maropitant treatment (T02) following a cisplatin‐induced‐emetic event resulted in significantly fewer subsequent emetic events (P= 0.0005) than in placebo‐treated dogs (T01). In placebo‐treated (T01) dogs, 56.4% were withdrawn from the study because of treatment failure compared with 5.3% in group T02. When maropitant was administered prior to cisplatin treatment (T03) in a prevention regime, 94.9% did not vomit compared with only 4.9% of placebo‐treated dogs, and significantly fewer emetic events (P< 0.0001) were observed in those dogs that did vomit. In summary, maropitant was safe and highly effective in reducing or completely preventing cisplatin‐induced emesis.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/j.1476-5829.2006.00123.x