Peer-reviewed veterinary case report
Efficacy of SPK-843, a novel polyene antifungal, in a murine model of systemic cryptococcosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2008
- Authors:
- Kakeya, Hiroshi et al.
- Affiliation:
- Department of Molecular Microbiology and Immunology · Japan
Abstract
SPK-843, a new polyene antifungal, possessed efficacy in a murine model of systemic infection caused by Cryptococcus neoformans. The administration of 4.0 mg/kg SPK-843 led to better survival prolongation and fungal reduction than those observed with the administration of 0.7 mg/kg amphotericin B and 80 mg/kg fluconazole (P < 0.001), without histopathological renal changes.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18299408/