Peer-reviewed veterinary case report
Efficacy of SPK-843, a novel polyene antifungal, in comparison with amphotericin B, liposomal amphotericin B, and micafungin against murine pulmonary aspergillosis.
- Journal:
- Antimicrobial agents and chemotherapy
- Year:
- 2008
- Authors:
- Kakeya, Hiroshi et al.
- Affiliation:
- Department of Molecular Microbiology and Immunology · Japan
Abstract
SPK-843, a new polyene antifungal, exhibited dose-dependent efficacy on murine pulmonary aspergillosis models. SPK-843 doses of higher than 1.0 mg/kg of body weight exhibited no renal toxicities and a tendency toward better survival prolongation than the estimated maximum tolerated doses of amphotericin B (Fungizone) (1.0 mg/kg) and liposomal amphotericin B (AmBisome) (8.0 mg/kg).
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18299412/