Peer-reviewed veterinary case report
Fatty acid differences in red blood cells of dogs with atopic
By Fuhrmann, Herbert et al.·Published in Canadian journal of veterinary research = Revue canadienne de recherche veterinaire·2006·Institute of Biochemistry, Germany·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Erythrocyte and plasma fatty acid patterns in dogs with atopic dermatitis and healthy dogs in the same household.
- Species:
- dog
Plain-English summary
An 8-year-old dog with atopic dermatitis (a skin condition causing itching and inflammation) was studied alongside a healthy dog from the same household. Researchers found that the dog with atopic dermatitis had different fatty acid patterns in its blood compared to its healthy housemate, suggesting a possible issue with how its body processes certain fats. This could explain some of the skin problems seen in dogs with this condition. Understanding these differences may help in developing better treatments for dogs suffering from atopic dermatitis.
People also search for: dog atopic dermatitis treatment · why is my dog itching · fatty acid supplements for dogs with skin problems
Abstract
Recent studies have indicated that dogs with canine atopic dermatitis (CAD) may have a disorder of fatty acid metabolism: possibly low or absent activity of delta6-desaturase or delta5-desaturase, or both. To clarify this possibility, we examined the erythrocyte and plasma fatty acid patterns of 8 dogs with CAD and their 8 healthy housemates. Atopic dermatitis was diagnosed according to the criteria proposed by Willemse; other causes of dermatitis were excluded clinically and by appropriate tests. Erythrocyte ghosts were prepared from blood samples. Membrane lipids were extracted and separated by thin-layer chromatography. From plasma and lipid fractions, fatty acid content was determined by gas chromatography. In erythrocytes, but not in plasma, we observed significant differences in the fatty acid pattern that suggested a reduction in the n6 fatty acid products of the delta6- and delta5-desaturases in dogs with atopic dermatitis when compared with healthy housemates.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16850941/