Peer-reviewed veterinary case report
High anti-Müllerian hormone in dog with Sertoli cell tumor
By Ano, Hitoshi et al.·Published in Veterinary dermatology·2014·View original on PubMed →
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Original publication title: Evaluation of anti-Müllerian hormone in a dog with a Sertoli cell tumour.
- Species:
- dog
Plain-English summary
A 6-year-old male Pembroke Welsh corgi was brought in for hair loss that wasn't itchy. The vet found that one of his testicles had not descended (cryptorchidism) and blood tests showed high levels of estradiol, a hormone often elevated in dogs with testicular tumors. The vet surgically removed the undescended testicle, and it was confirmed to have a Sertoli cell tumor. After surgery, the dog's hormone levels returned to normal, suggesting that measuring certain hormones could help diagnose this type of tumor in dogs.
People also search for: dog hair loss · cryptorchidism in dogs · Sertoli cell tumor treatment · high estradiol in dogs
Abstract
BACKGROUND: Testicular tumours are common in elderly male dogs, and Sertoli cell tumours (SCTs) are among the most common. An increase in blood estradiol concentration is often seen in canine SCTs, but such measurements do not necessarily correlate with the clinical signs. CASE REPORT: A 6-year-old male Pembroke Welsh corgi was referred for nonpruritic alopecia. Clinical examination revealed cryptorchidism of the right testicle, and blood tests showed an increased estradiol concentration. The cryptorchid testis was removed by laparotomy, and SCT was diagnosed histologically. An enzyme-linked immunosorbent assay kit designed to measure human anti-Müllerian hormone (AMH) revealed a very high preoperative serum AMH concentration, which decreased after surgery. The serum AMH concentrations of two intact healthy control male dogs were lower than that of the dog with the SCT before treatment but higher than thoseof two healthy castrated male dogs. CONCLUSIONS AND CLINICAL IMPORTANCE: Canine serum AMH concentrations, as measured by a human AMH enzyme-linked immunosorbent assay, may be useful as a marker for canine SCT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24800267/