Peer-reviewed veterinary case report
Blood vessel lining damage markers in cats with hemotropic
By Ider, Merve et al.·Published in Scientific reports·2024·Department of Internal Medicine·View original on PubMed →
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Original publication title: Evaluation of endothelial glycocalyx injury biomarkers in feline hemotropic mycoplasmosis.
- Species:
- cat
Plain-English summary
A group of 25 cats with hemotropic mycoplasmosis, an infection caused by Mycoplasma haemofelis, were studied to understand the damage to their blood vessel lining. Symptoms included various health issues, and tests showed that 14 of the cats survived while 11 did not. Researchers found that certain biomarkers in the blood, specifically syndecan-1 and endothelin-1, were significantly higher in the sick cats compared to healthy ones, indicating potential diagnostic value. The study suggests that these biomarkers could help veterinarians assess the severity of the disease and predict outcomes for affected cats.
People also search for: cat hemotropic mycoplasmosis symptoms · feline mycoplasmosis treatment · elevated endothelin-1 in cats
Abstract
The present study aimed to investigate endothelial glycocalyx (eGCx) damage in cats with feline hemotropic mycoplasmosis caused by Mycoplasma haemofelis using selected biomarkers and to determine the diagnostic and prognostic significance of these biomarkers. The study included 25 cats with feline hemotropic mycoplasmosis and 10 healthy cats. Clinical examination, blood gas analysis, complete blood count, and biochemical analysis were performed. Hemotropic mycoplasmosis diagnosed by microscopic examination and molecularly confirmed by PCR targeting the Mycoplasma haemofelis 16s rRNA gene. To evaluate endothelial glycocalyx damage, syndecan-1, endothelin-1 (ET-1), asymmetric dimethylarginine (ADMA), and vascular endothelial growth factor-A (VEGF-A) concentrations were measured using cat-specific commercial ELISA kits. Of the cats with feline hemotropic mycoplasmosis, 14 (56%) survived and 11 (44%) died. While syndecan-1 and ET-1 concentrations were significantly higher in cats with hemotropic mycoplasmosis compared to the control group (p < 0.001), no statistically significant difference was found for ADMA and VEGF-A concentrations (p > 0.05). Endothelial glycocalyx biomarkers showed significant correlations with each other and with hematological parameters (p < 0.01). The results of the ROC analysis showed that ET-1 with area under the curve (AUC) of 0.821 (p < 0.01) and VEGF-A with AUC of 0.805 (p < 0.010) were found to be significant prognostic indicators. In conclusion, this study demonstrated that serum syndecan-1 and ET-1 can be used as diagnostic and serum ET-1 and VEGF-A as prognostic biomarkers in cats with hemotropic mycoplasmosis. Our results indicate the development of eGCx damage in feline hemotropic mycoplasmosis and suggest that glycocalyx disruption may contribute to the pathogenesis of the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38839816/