Peer-reviewed veterinary case report
How well fructosamine shows blood sugar control in diabetic dogs
By Zeugswetter, Florian K et al.·Published in The Veterinary record·2022·Clinical Department for Small Animals and Horses·View original on PubMed →
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Original publication title: Evaluation of fructosamine concentration as an index marker for glycaemic control in diabetic dogs.
- Species:
- dog
Plain-English summary
A group of 24 diabetic dogs were monitored for their blood sugar levels over about 13 days to see how well fructosamine, a blood test, could indicate their diabetes control. The study found that fructosamine levels did not reliably predict whether the dogs had good or poor control of their diabetes. While it showed some moderate accuracy, it is not a perfect test and should be used alongside regular glucose monitoring for the best results. Pet owners should discuss with their vet how to best manage their dog's diabetes using both tests.
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Abstract
BACKGROUND: Although fructosamine is a commonly used surrogate marker to assess glycaemic control in diabetic dogs, its diagnostic accuracy has been questioned. The main objective of this study was to evaluate the reliability of fructosamine measurements to diagnose well and poorly controlled diabetes mellitus (DM), using continuous glucose monitoring as a gold standard. METHODS: Twenty-four dogs with treated DM and continuous glucose monitoring for mean (±SD) 13.1 (±1.7) days were retrospectively analysed. Two assessment strategies were applied to categorize glycaemic control, and fructosamine concentrations were determined shortly after sensor cessation using a colorimetric assay. RESULTS: Correlations of individual fructosamine concentrations with mean glucose as well as percentage of measurements > 15 mmol/L were not significant (p = 0.372, p = 0.129). Fructosamine did not differ between dogs with and without hypoglycaemic episodes (p = 0.64). Receiver operating characteristic analysis for fructosamine to diagnose either good or poor glycaemic control revealed AUC values of 0.71 (p = 0.025) indicating moderate accuracy, and 0.7 (p = 0.135) indicating AUC is non-discriminatory, respectively. The respective positive likelihood ratios for the optimal cutoffs to identify good (<396 μmol/L) and poor control (>449 μmol/L) were three. CONCLUSIONS: Fructosamine measurement is an imperfect surrogate marker for classifying glycaemic control in diabetic dogs and can only complement serial glucose measurements.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33870504/