Peer-reviewed veterinary case report
Outcomes of high calcium and kidney injury in dogs with lymphoma
By Strumpf, Alyssa A et al.·Published in Journal of veterinary internal medicine·2024·The Ohio State University, United States·View original on PubMed →
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Original publication title: Evaluation of the clinical outcome of hypercalcemia of malignancy and concurrent azotemia in dogs with lymphoma.
- Species:
- dog
Plain-English summary
A group of 29 dogs with lymphoma and high calcium levels (hypercalcemia) were treated with chemotherapy after showing signs of kidney injury. After starting treatment, all the dogs had their high calcium levels resolved, and about 79% saw improvement in their kidney function. The study found that the severity of kidney injury at diagnosis influenced recovery, but overall, serious kidney-related deaths were rare. Most dogs responded well to the treatment, and some were still alive or being monitored at the end of the study.
People also search for: dog lymphoma treatment · high calcium levels in dogs · dog kidney injury recovery · chemotherapy for dogs with lymphoma
Abstract
BACKGROUND: Hypercalcemia of malignancy (HM) secondary to lymphoma in dogs has the potential to cause renal injury. HYPOTHESIS/OBJECTIVES: Characterize outcomes related to acute kidney injury (AKI) secondary to HM. We hypothesized that dogs do suffer AKI regardless of HM severity at the time of lymphoma diagnosis or relapse. ANIMALS: Retrospective study. Twenty-nine dogs with lymphoma, HM, and azotemia (International Renal Interest Society [IRIS] grade II or higher AKI) that underwent chemotherapy were identified at 2 veterinary institutions. METHODS: Logistic regression and descriptive statistical analysis were performed to evaluate data for potential prognostic factors. RESULTS: After initiating treatment, resolution of hypercalcemia and azotemia occurred in 100% (29/29) and 79.3% (23/29) of dogs, respectively. Resolution of azotemia was influenced by serum creatinine concentration (odds ratio [OR], 0.148; Confidence interval [CI], 0.03-0.734; P = .02) and total hypercalcemia (OR, 0.36; CI, 0.14-0.93; P = .04) at diagnosis, whereas blood urea nitrogen concentration, IRIS grade, sex, and whether or not dogs were hospitalized were not significant factors. At data analysis, 13.8% (4/29) of dogs were alive or lost to follow-up. Of those dead, 4 dogs (15%) had renal disease at the time of death, 2/4 having concurrent lymphoma progression. CONCLUSIONS AND CLINICAL IMPORTANCE: Although AKI may be of clinical concern in dogs with HM secondary to lymphoma at diagnosis, death secondary to renal impairment appears to be infrequent.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38131263/