Peer-reviewed veterinary case report
Anti-insulin antibodies found in some diabetic dogs on human insulin
By Lester, M. & O'Kell, A. L.·Published in Journal of Small Animal Practice·2020·Small Animal Hospital, College of Veterinary Medicine University of Florida Gainesville Florida 32608 USA, United States·View original on Crossref →
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Original publication title: Exploratory analysis of anti‐insulin antibodies in diabetic dogs receiving recombinant human insulin
- Species:
- dog
Plain-English summary
A group of 24 diabetic dogs receiving human insulin for their diabetes was tested for the presence of anti-insulin antibodies, which can affect how well the insulin works. Out of these dogs, 4 (about 16.6%) had these antibodies, while none of the healthy dogs did. This suggests that some diabetic dogs may develop antibodies against the insulin they are given, which could impact their blood sugar control. Further research is needed to understand how these antibodies affect treatment outcomes.
People also search for: dog diabetes treatment · insulin antibodies in dogs · diabetic dog blood sugar control
Abstract
ObjectivesTo quantify anti‐insulin antibodies in diabetic dogs treated with recombinant human insulin and to determine if insulin dosage or duration of treatment differed between anti‐insulin antibody‐positive and ‐negative diabetic dogs.Materials and MethodsDescriptive preliminary study using serum from 24 client‐owned diabetic dogs treated for a minimum of 2 weeks with recombinant human insulin, and 24 client‐owned healthy control dogs without diabetes. Sera were analysed by radioimmunoassay for anti‐insulin antibodies. The proportion of antibody positive dogs was compared between groups by Fisher's exact test.ResultsFour diabetic (16.6%) and no control dogs were anti‐insulin antibody positive.Clinical SignificanceThese results indicate that treatment with recombinant human insulin may induce anti‐insulin antibodies in dogs, although this finding needs to be re‐investigated in a larger study to investigate the impact of anti‐insulin antibodies on glycaemic control.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/jsap.13102