Peer-reviewed veterinary case report
TRPM7 protein levels linked to dog mammary tumor outcomes
By Lee, Seulji et al.·Published in Veterinary and Comparative Oncology·2021·Department of Veterinary Clinical Sciences, College of Veterinary Medicine and Research Institute for Veterinary Science Seoul National University Seoul Republic of Korea, South Korea·View original on Crossref →
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Original publication title: Expression and prognostic value of TRPM7 in canine mammary tumours
- Species:
- dog
Plain-English summary
A study looked at the presence of a protein called TRPM7 in mammary tumors from female dogs, which are common in intact females. Researchers found that higher levels of TRPM7 were linked to more aggressive tumors and a worse prognosis for the dogs. This means that if a dog has a malignant mammary tumor with high TRPM7 expression, it may have a lower chance of surviving without the disease returning. Understanding TRPM7 could help veterinarians predict outcomes for dogs with these tumors and guide treatment decisions.
People also search for: dog mammary tumor prognosis · TRPM7 in dog cancer · canine mammary gland tumor treatment
Abstract
AbstractCanine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Ca2+ and Mg2+ permeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki‐67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease‐free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs.
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Search related cases →Original publication on Crossref: https://doi.org/10.1111/vco.12689