Peer-reviewed veterinary case report
TRPM7 protein levels linked to dog mammary tumor outcomes
By Lee, Seulji et al.·Published in Veterinary and comparative oncology·2021·Department of Veterinary Clinical Sciences, South Korea·View original on PubMed →
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Original publication title: Expression and prognostic value of TRPM7 in canine mammary tumours.
- Species:
- dog
Plain-English summary
A study looked at mammary tumors in female dogs and found that a specific protein called TRPM7 is present in these tumors. This protein's levels were linked to how aggressive the tumor was and how likely it was to spread. Higher levels of TRPM7 were associated with a shorter time before the disease worsened and a lower overall survival rate. This suggests that measuring TRPM7 could help veterinarians predict how a dog with a mammary tumor might do in the future.
People also search for: dog mammary tumor prognosis · TRPM7 in canine tumors · female dog breast cancer treatment
Abstract
Canine mammary gland tumour (CMTs) are one of the most commonly found tumours in intact female dogs. A previous study on canine mammary glands demonstrated the presence of the transient receptor potential melastatin 7 (TRPM7) ion channels in healthy canine mammary tissues. However, the significance of TRPM7 in CMT is not yet known. TRPM7 is a Caand Mgpermeable cation channel that contains a protein kinase domain. The aim of this study was to determine TRPM7 expression in 57 benign and malignant CMT tissues of dogs using immunohistochemistry (IHC) and evaluate its correlation with clinicopathological features and explore the potential prognostic value of TRPM7 in a prospective survival study. IHC analysis shows that TRPM7 was expressed in the cytoplasm of neoplastic epithelial cells. Moreover, TRPM7 expression was significantly associated with tumour malignancy (P = .027), Ki-67 index (P < .0001) and metastasis (P < .0001). Survival curve analysis indicates that high TRPM7 expression was significantly associated with poor disease-free (P = .035) and overall survival (P = .011) in malignant CMTs. Our results demonstrate that TRPM7 is expressed in CMTs and that its expression is positively correlated with clinicopathological parameters. Thus, TRPM7 was assumed to be a potential prognostic factor for CMTs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/33617107/