Peer-reviewed veterinary case report
E-cadherin and beta-catenin levels linked to dog mammary tumor
By Gama, Adelina et al.·Published in Veterinary journal (London, England : 1997)·2008·Department of Veterinary Sciences·View original on PubMed →
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Original publication title: Expression of E-cadherin, P-cadherin and beta-catenin in canine malignant mammary tumours in relation to clinicopathological parameters, proliferation and survival.
- Species:
- dog
Plain-English summary
A study looked at 65 dogs with malignant mammary tumors, finding that lower levels of certain proteins (E-cadherin and beta-catenin) were linked to larger tumors and more aggressive disease. Dogs with reduced E-cadherin and beta-catenin had a shorter survival time and were more likely to have their cancer spread. This suggests that monitoring these proteins could help predict how a dog's cancer might progress. Treatment options weren't specified, but understanding these markers could guide veterinarians in managing the disease more effectively.
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Abstract
Cadherin-catenin complexes play a critical role in intercellular adhesion, and their altered expression has been implicated in tumour progression. In this study, the expression of E-cadherin, P-cadherin and beta-catenin was analysed in 65 canine malignant mammary tumours and correlated with clinicopathological parameters, proliferation and survival. Reduction in E-cadherin expression was significantly associated with increased tumour size, high histological and invasion grades, lymph node metastasis and high mitotic index. Reduced beta-catenin expression was associated with high histological and invasion grades. Anomalous expression of P-cadherin was only associated with invasion. In 39 cases for which follow-up data were available, reduced E-cadherin and beta-catenin expression was significantly associated with shorter overall survival and disease free survival. Abnormal expression of adhesion molecules is a common phenomenon in canine mammary malignant tumours and may play a central role in tumour progression.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17631398/