Peer-reviewed veterinary case report
iNOS, COX-2, and VEGF levels linked to dog mammary tumor severity
By Anadol, Elvan et al.·Published in Acta veterinaria Hungarica·2017·1 Gazi University Laboratory·View original on PubMed →
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Original publication title: Expression of iNOS, COX-2 and VEGF in canine mammary tumours and non-neoplastic mammary glands: Association with clinicopathological features and tumour grade.
- Species:
- dog
Plain-English summary
A group of 35 female dogs aged 6 to 10 years was examined for mammary masses, which can be a sign of breast tumors. Researchers found that certain markers (iNOS, COX-2, and VEGF) were present at higher levels in both benign and malignant tumors compared to healthy tissue. The levels of these markers increased with the severity of the tumor, meaning that dogs with more aggressive tumors had higher amounts of these substances. This information can help veterinarians understand the nature of mammary tumors in dogs and guide treatment decisions.
People also search for: dog mammary tumor symptoms · treatment for dog breast cancer · what causes lumps in dog breasts
Abstract
The aim of the present study was to investigate the relationship between the expression of iNOS, COX-2 and VEGF mRNA levels and malignancy degree in canine malignant mammary tumours. Thirty-five bitches presented with the complaint of mammary masses, aged 6-10 years and representing different breeds, were used. The expressions of iNOS, COX-2 and VEGF mRNA levels were significantly higher in both benign and malignant tumours than in the adjacent nonneoplastic mammary glands (P < 0.05). The iNOS, COX-2 and VEGF mRNA expression levels of grade 2 tumours were higher than those of grade 1 tumours; however, the highest expression levels were detected in grade 3 tumours. Thus, increased iNOS, COX-2 and VEGF gene mRNA levels were found to be related with the histological grade of malignancy in dogs with mammary tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28956485/