Peer-reviewed veterinary case report
Periostin protein found in cancer cells of female dogs' mammary tumors
By Borecka, Paulina et al.·Published in In vivo (Athens, Greece)·2020·Department of Pathology·View original on PubMed →
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Original publication title: Expression of Periostin in Cancer-associated Fibroblasts in Mammary Cancer in Female Dogs.
- Species:
- dog
Plain-English summary
A study looked at mammary tumors in female dogs, which are common cancers similar to breast cancer in women. Researchers found that a protein called periostin was present in 92% of malignant tumors but only in 25% of benign tumors. This suggests that periostin could be linked to how aggressive the cancer is and might help veterinarians assess the severity of the disease. Understanding periostin's role could lead to better ways to evaluate and treat mammary cancer in female dogs.
People also search for: dog mammary tumor treatment · periostin in dog cancer · female dog breast cancer signs
Abstract
BACKGROUND/AIM: Mammary neoplasms, like breast neoplasms in women, are one of the most common tumours in female dogs. Cancer-associated fibroblasts (CAFs) found in the tumour stroma play a role in angiogenesis and increase cell migration, contributing to tumour growth and progression, as well as metastasis. The aim of our work was to determine the level of periostin (POSTN) expression in CAFs in mammary tumours of female dogs. MATERIALS AND METHODS: The research material consisted of 77 carcinomas and 24 adenomas of the mammary ridge in female dogs. Immunohistochemistry tests were performed using antibodies directed against the antigens POSTN, Ki-67, ERB-B2 receptor tyrosine kinase 2 (HER2), vimentin, and alpha smooth muscle actin (αSMA). Expression of POSTN at the mRNA level was determined using real-time polymerase chain reaction methods in 20 cases of mammary neoplasms. RESULTS: Expression of POSTN in CAFs was observed in 92% of mammary cancer samples and in 25% of mammary adenoma samples in female dogs. A statistically significant increase in POSNT expression in CAFs was found in the carcinomas compared with mammary adenomas in female dogs. Expression of POSTN in CAFs in mammary carcinomas in female dogs positively correlated with the histological malignancy grade of tumours and the expression of Ki-67 proliferative antigen. CONCLUSION: Our results suggest a role of POSTN on the pathogenesis of mammary tumours in female dogs. Moreover, POSTN may prove to be a useful marker in the evaluation of cancerous stroma of mammary tumours in female dogs, and may have prognostic significance.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32354887/