Peer-reviewed veterinary case report
Extramedullary blood cell formation in a female dog's benign mammary
By Grandi, Fabrizio et al.·Published in BMC veterinary research·2010·Department of Clinical Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Extramedullary hematopoiesis in a case of benign mixed mammary tumor in a female dog: cytological and histopathological assessment.
- Species:
- dog
Plain-English summary
A 7-year-old female mongrel dog had a nodule in her left inguinal mammary gland and was diagnosed with a benign mixed mammary tumor. During testing, doctors found unusual blood cell production happening outside of the bone marrow, a condition known as extramedullary hematopoiesis (EMH). Fortunately, the dog did not have any blood-related issues, and the tumor was confirmed to be benign. While EMH is rare, it can occur with certain types of mammary tumors. The dog is expected to be fine since the tumor was not cancerous.
People also search for: dog mammary tumor symptoms · benign tumor in dog · extramedullary hematopoiesis in dogs
Abstract
BACKGROUND: Extramedullary hematopoiesis (EMH) is defined as the presence of hematopoietic stem cells such as erythroid and myeloid lineage plus megakaryocytes in extramedullary sites like liver, spleen and lymph nodes and is usually associated with either bone marrow or hematological disorders. Mammary EMH is a rare condition either in human and veterinary medicine and can be associated with benign mixed mammary tumors, similarly to that described in this case. CASE PRESENTATION: Hematopoietic stem cells were found in a benign mixed mammary tumor of a 7-year-old female mongrel dog that presents a nodule in the left inguinal mammary gland. The patient did not have any hematological abnormalities. Cytological evaluation demonstrated two distinct cell populations, composed of either epithelial or mesenchymal cells, sometimes associated with a fibrillar acidophilic matrix, apart from megakaryocytes, osteoclasts, metarubricytes, prorubricytes, rubricytes, rubriblasts, promyelocytes, myeloblasts. Histological examination confirmed the presence of an active hematopoietic bone marrow within the bone tissue of a benign mammary mixed tumor. CONCLUSIONS: EMH is a rare condition described in veterinary medicine that can be associated with mammary mixed tumors. It's detection can be associated with several neoplastic and non-neoplastic mammary lesions, i.e. osteosarcomas, mixed tumors and bone metaplasia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20846427/