Peer-reviewed veterinary case report
FGF-23 and Alpha-Klotho levels in dogs with canine Leishmaniasis
By Gultekin, Gamze & Ulutas, Pinar Alkim·Published in Research in veterinary science·2024·Department of Biochemistry·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Fibroblast growth factor-23 and Alpha-Klotho concentrations in dogs with canine Leishmaniasis.
- Species:
- dog
Plain-English summary
A group of dogs with Canine Leishmaniasis (CanL) showed higher levels of certain proteins related to kidney function compared to healthy dogs. Researchers found that as the disease progressed, particularly in the advanced stages, levels of Fibroblast Growth Factor-23 (FGF-23) increased significantly, which was linked to worsening kidney function. This suggests that monitoring FGF-23 could help veterinarians assess the severity of kidney issues in dogs with CanL. Understanding these changes may lead to better diagnostic and treatment options for affected dogs.
People also search for: dog kidney disease Canine Leishmaniasis · high FGF-23 in dogs · CanL treatment options · dog kidney function tests
Abstract
This study aimed to assess the concentrations of Fibroblast Growth Factor-23 (FGF-23) and α-Klotho in healthy dogs and dogs at different stages of Canine Leishmaniasis (CanL), and investigate the changes of these parameters in relation to renal function and calcium‑phosphorus metabolism. A total of 74 dogs (22 healthy and 52 with CanL) of varying ages, sexes, and medium-sized breeds were included. Dogs with CanL were categorized into different stages (Stage I-IV) based on Leishvet recommendations. In addition to routine hematological parameters, plasma FGF-23, serum α-Klotho, urea, creatinine, phosphorus, calcium, parathormone, vitamin D concentrations, and urine protein/creatinine ratio were measured. Data from healthy dogs were compared to dogs with CanL overall and by stage. Dogs with CanL exhibited higher concentrations of FGF-23 (p < 0.05), α-Klotho, and parathormone (p < 0.001), as well as lower concentrations of vitamin D and calcium (p < 0.001). FGF-23 concentration was particularly elevated in Stage IV compared to other stages. However, no significant differences in α-Klotho levels were observed among the stages. FGF-23 levels showed a weak positive correlation with urea and creatinine concentrations and a moderate positive correlation with urine protein/creatinine ratio. This study demonstrated increased levels of FGF-23 and α-Klotho in dogs with CanL for the first time. The increase in FGF-23 levels was more prominent in advanced stages of the disease and correlated with higher urea and creatinine concentrations. These findings may serve as a basis for future diagnostic and therapeutic investigations, contributing to the understanding of the pathophysiology of kidney disease in CanL.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/38547738/