Peer-reviewed veterinary case report
Genetic variations in BRCA1 and BRCA2 linked to dog mammary tumors
By Enginler, S O et al.·Published in Veterinary research communications·2014·Faculty of Veterinary Medicine·View original on PubMed →
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Original publication title: Genetic variations of BRCA1 and BRCA2 genes in dogs with mammary tumours.
- Species:
- dog
Plain-English summary
A study found that certain genetic changes in the BRCA1 and BRCA2 genes may be linked to mammary tumors in female dogs. Mammary tumors are the most common type of tumor in female dogs, and this research suggests that specific variations in these genes could increase the risk of developing these tumors. The researchers identified new genetic markers that may help in understanding which dogs are more likely to develop mammary tumors. This information could be useful for breeders and veterinarians in managing the health of female dogs, especially those at higher risk.
People also search for: dog mammary tumor genetics · female dog tumor risk · BRCA1 BRCA2 in dogs
Abstract
Mammary tumours are the most common tumour type in female dogs. The formation of the mammary tumours is multifactorial but the high incidence of tumour disease in certain canine breeds suggests a strong genetic component. BRCA1 and BRCA2 are the most important genes significantly associated with mammary tumours. The aim of this study was to determine the association between the variations of these two genes and canine mammary tumours. 5'-untranslated region, intron 8 and exon 9 of BRCA1 and exons 12, 24, 27 of BRCA2 were sequenced in order to detect the genetic variations. In addition to six previously identified polymorphisms, six novel single nucleotide polymorphisms (SNPs) were detected. Five of the coding SNPs were synonymous and three of them were non-synonymous. The comparison of the sequences from 25 mammary tumour bearing and 10 tumour free dogs suggested that the two SNPs in intron 8 and exon 9 of BRCA1 and two SNPs in exon 24 and exon 27 of BRCA2, which are firstly identified in this study, might be associated with mammary tumour development in dogs. Especially one SNP in exon 9 of BRCA1 and one SNP in exon 24 of BRCA2 were found to be significantly associated with canine mammary tumours.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/24122022/