Peer-reviewed veterinary case report
Two female dogs with acromegaly caused by growth hormone mammary
By Murai, Atsuko et al.·Published in The Journal of veterinary medical science·2012·Yuki Animal Hospital, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: GH-producing mammary tumors in two dogs with acromegaly.
- Species:
- dog
Plain-English summary
Two female dogs were brought to the vet because they had growing mammary tumors and signs of acromegaly, which included weight gain, a larger head, extra skin folds, and breathing difficulties. Tests showed high levels of growth hormone and related substances, confirming the diagnosis of acromegaly. One dog had her tumors and ovaries removed, while the other had only the tumors taken out. After surgery, both dogs showed improvement, with their hormone levels returning to normal.
People also search for: dog mammary tumor treatment · acromegaly in dogs · dog weight gain and skin folds · dog breathing problems · dog surgery for tumors
Abstract
Two intact female dogs were admitted for growing mammary tumors. They had symptoms of acromegaly including weight gain, enlargement of the head, excessive skin folds, and inspiratory stridor. Serum concentrations of growth hormone (GH), insulin-like growth factor-I (IGF-I), and insulin were elevated in the two cases. From these findings, both dogs were diagnosed with acromegaly. In case 1, the GH, IGF-I, and insulin levels subsided after removal of the focal benign mammary tumors and ovariohysterectomy. In case 2, those levels subsided after removal of only focal mammary carcinoma. In both cases, immunohistochemical investigations for GH were positive in the mammary tumor cells but not in the normal mammary glands. We concluded that GH-producing mammary tumors caused the present acromegaly.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22214858/