Peer-reviewed veterinary case report
Kidney filtration rate in dogs with leishmaniasis and kidney disease
By Cortadellas, O et al.·Published in Journal of veterinary internal medicine·2008·Clí, Spain·View original on PubMed →
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Original publication title: Glomerular filtration rate in dogs with leishmaniasis and chronic kidney disease.
- Species:
- dog
Plain-English summary
A group of dogs with kidney disease caused by leishmaniasis were tested to see how well their kidneys were filtering waste. The study found that some dogs had low kidney function, while others showed signs of overworking kidneys. Specifically, 11 out of the 26 dogs had an abnormally low filtration rate, which can indicate worsening kidney health. This information can help veterinarians better understand kidney function in dogs with this condition and tailor treatments accordingly.
People also search for: dog kidney disease leishmaniasis · low kidney function in dogs · chronic kidney disease treatment for dogs
Abstract
BACKGROUND: Glomerular filtration rate (GFR) measurement is an indicator of kidney function. However, its usefulness in dogs at early stages of spontaneous chronic kidney disease (CKD) of glomerular origin, where routine laboratory techniques are not sufficiently sensitive, remains unproved. HYPOTHESIS: That GFR is reduced in proteinuric nonazotemic or mildly azotemic dogs with CKD secondary to leishmaniasis. ANIMALS: Twenty-six dogs with CKD secondary to leishmaniasis and 10 healthy dogs (control group). METHODS: CBC, serum biochemistry, and urinalysis (microalbuminuria and urine protein/creatinine ratio [UPC]) were performed in all dogs. GFR was calculated by measuring exogenous creatinine clearance. Based on degree of proteinuria and serum creatinine concentration (SCr), dogs were classified as group A (control; n = 10): UPC < 0.2, SCr < 1.4 mg/dL; group B (n = 8): UPC, 0.2-0.5, SCr < 1.4 mg/dL; group C (n = 10): UPC > 0.5, SCr < 1.4 mg/dL; group D (n = 5): SCr, 1.4-2 mg/dL; group E (n = 3): SCr > 2 mg/dL. RESULTS: GFR (mL/kg/min) was 3.9 +/- 0.29, 4.4 +/- 0.74, 4.5 +/- 1.44, 2.8 +/- 0.97, and 1.5 +/- 0.43 for groups A, B, C, D, and E, respectively. Eleven dogs (1 from group B, 3 from group C, 4 from group D, and all 3 dogs from group E) had an abnormally low GFR. Four dogs from group B and 5 dogs from group C had a GFR above the upper reference range (>4.5 mL/min/kg). CONCLUSION AND CLINICAL RELEVANCE: Some proteinuric nonazotemic or mildly azotemic dogs with leishmaniasis have low GFR, but glomerular hyperfiltration occurs in other dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18371023/