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Peer-reviewed veterinary case report

Dog with persistent estrus 6 years after spay had ovarian tumor

By Pluhar, G E et al.·Published in Journal of the American Veterinary Medical Association·1995·Department of Veterinary Clinical Sciences, United States·View original on PubMed

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Original publication title: Granulosa cell tumor in an ovariohysterectomized dog.

Species:
dog

Plain-English summary

A 9-year-old female dog was brought in because she was showing signs of persistent heat (estrus) six years after being spayed. After tests including ultrasound and surgery, the vet discovered a granulosa cell tumor, which was causing hormone imbalances that led to hair loss and low blood cell counts. The treatment involved removing the tumor, giving blood transfusions, and providing antibiotics. Following these treatments, the dog recovered well.

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Abstract

A granulosa cell tumor was found in a dog with clinical signs of persistent estrus that began 6 years after ovariohysterectomy had been performed. The tumor was diagnosed by use of ultrasonography, provocative testing with human chorionic gonadotropin, and exploratory laparotomy. Hyperestrogenism from functional tumor cells caused bone marrow suppression and endocrine alopecia. Successful treatment included tumor removal, blood transfusions, and antibiotic administration.

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Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/7559047/