Peer-reviewed veterinary case report
Heart rate variability and norepinephrine in resting diabetic dogs
By Pirintr, Prapawadee et al.·Published in Veterinary research communications·2012·Faculty of Veterinary Science·View original on PubMed →
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Original publication title: Heart rate variability and plasma norepinephrine concentration in diabetic dogs at rest.
- Species:
- dog
Plain-English summary
A group of diabetic dogs was studied to see how their heart function was affected by their condition. The researchers found that dogs with poorly controlled diabetes had lower heart rate variability and higher heart rates compared to healthy dogs. These dogs also had lower levels of norepinephrine, a hormone related to stress response, indicating that their heart's nervous system was not functioning properly. In contrast, dogs with well-controlled diabetes showed better heart function. This suggests that managing diabetes effectively can help protect a dog's heart health.
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Abstract
Cardiac autonomic neuropathy in dogs with diabetic mellitus (DM) was evaluated using measurement of heart rate variability (HRV) and plasma norepinephrine (NE) concentration. Dogs were divided into 2 groups; the control non-DM group (n = 13) and the diabetic group (n = 22) which was further divided into the well-controlled DM (n = 11) and the poorly-controlled DM subgroups (n = 11) according to their fasting plasma fructosamine concentrations. The electrocardiogram (ECG) was recorded continuously for at least 30 min to yield HRV. The results showed that in the poorly-controlled DM subgroup, the average of normal R-R interval (mean N-N), SD of the mean of all 5-min segments of normal RR intervals (SDANN) were lower than the control group while heart rate was higher (P < 0.05). The NNA, SDNN, SDNN index and pNN50% were significantly lower when compared with the well-controlled DM subgroup (P < 0.05). The high frequency (HF) and total power were significantly lower while the ratio of low to high frequency (LF/HF) was higher (P < 0.05) when compared with the well-controlled DM subgroup. Moreover, in the poorly-controlled DM subgroup, plasma NE concentration was lower than the control group (210 ± 37 vs. 479 ± 74 pg/ml, P < 0.05). There was a significantly negative correlation between plasma NE and plasma fructosamine concentrations. It is concluded that cardiac autonomic neuropathy occurred in poorly-controlled DM dogs. The sympathetic activity was suppressed as shown by decrease in both plasma NE concentration and LF component.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22855304/