Peer-reviewed veterinary case report
High resistin levels in obese female dogs with mammary tumors
By Nicchio, Bianca Oliveira et al.·Published in Frontiers in veterinary science·2020·School of Veterinary Medicine, Brazil·View original on PubMed →
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Original publication title: Hyperresistinemia in Obese Female Dogs With Mammary Carcinoma in Benign-Mixed Tumors and Its Correlation With Tumor Aggressiveness and Survival.
- Species:
- dog
Plain-English summary
A group of 80 female dogs, some with mammary tumors (benign-mixed tumors) and some without, were studied to see how their weight and a protein called resistin affected their health and survival. The dogs with tumors who were overweight and had high resistin levels had a lower chance of survival compared to those with normal weight and lower resistin levels. The study found that the more aggressive the tumor (measured by a marker called Ki-67), the worse the outcome for the dogs. This suggests that monitoring resistin levels could help predict how well these dogs might do after being diagnosed with mammary tumors.
People also search for: dog mammary tumor prognosis · overweight dog cancer survival · high resistin levels in dogs
Abstract
Resistin is associated with metabolic, inflammatory, and neoplastic disorders, and is also considered a prognostic marker in human oncology. Canine mammary tumors have epidemiological, clinical, biological, and genetic characteristics similar to those of women and are proposed as a comparative study model. Here, we evaluate the serum levels of resistin in female dogs with or without mammary carcinoma in mixed tumors (CBMT) and its correlation with the proliferative potential of the tumor, obesity, and survival. Eighty dogs grouped according to the presence (50) or absence (30) of CBMT, reproductive status and body condition were assessed for weight, fat percentage, and canine body mass index. The characteristic of the proliferative potential of the tumor (Ki-67) was evaluated. Ki-67 levels (= 0.024), staging (= 0.004), and grade (= 0.016) influenced the survival of the female dogs. Through a multifactorial analysis, it could be seen that the parameters proliferation index (Ki-67) (= 0.044) and staging (= 0.036) influenced the survival of the animals. Neutered and overweight dogs from the control and CBMT groups showed hyperresistinemia. Ki-67 expression and resistin levels in dogs with CBMT were higher in overweight dogs than in dogs with normal weight (= 0.0001). The survival rate of dogs with CBMT, obese and with high levels of resistin (8,400 μg L) was lower when compared to those with lower levels of resistin. These results showed an important relationship between hyperresistinemia, tumor proliferative potential and excessive body fat, suggesting that resistin levels may act as an interesting prognostic marker in patients with CBMT.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32903534/