Peer-reviewed veterinary case report
Blood test changes linked to obesity problems in dogs
By Tvarijonaviciute, A et al.·Published in Veterinary journal (London, England : 1997)·2019·University of Murcia, Spain·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Identification of changes in serum analytes and possible metabolic pathways associated with canine obesity-related metabolic dysfunction.
- Species:
- dog
Plain-English summary
A group of overweight dogs was tested to understand how obesity affects their health. The study found that dogs with obesity-related metabolic dysfunction (ORMD) had higher levels of certain substances in their blood, indicating issues with liver function, inflammation, and metabolism. These changes could lead to further health problems, including issues with blood clotting and lung function. The findings suggest that managing a dog's weight is crucial for preventing these serious health issues.
People also search for: dog obesity health problems · overweight dog liver function · managing canine obesity
Abstract
The main objective of this study was to identify analytes that could change and that could help to clarify the metabolic and physiopathological changes related to canine obesity-related metabolic dysfunction (ORMD). For this, serum from 35 overweight/obese dogs, with and without ORMD, was submitted to a comprehensive panel of biochemistry analysis, a gel-free tandem mass tag isobaric label-based proteomic analysis, and, finally, selected proteins were used as a starting point for creating a protein interaction network. Dogs with ORMD showed significantly higher serum concentrations of alanine aminotransferase (ALT), alkaline phosphatase (ALP), Ca, total proteins, albumin, total cholesterol, triglycerides, glucose, and butyrylcholinesterase (BChE) activity in comparison with dogs without ORMD. Proteomic analysis revealed that 23 proteins related to lipid metabolism, the complement factor system, cellular adhesion and functionality, inflammation, and coagulation were altered in dogs with ORMD. Finally, the obtained protein interaction network highlighted that the central term of this network was the negative regulation of the immune response. These data suggest that canine ORMD is associated with changes in analytes that reflect altered lipid metabolism, and liver and immune function impairment and suggests the potential for a prothrombotic state and lung function alterations.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30825895/