Peer-reviewed veterinary case report
Identifying triple-negative basal-like mammary tumors in dogs
By Kim, N H et al.·Published in Journal of comparative pathology·2013·Department of Veterinary Pathology, South Korea·View original on PubMed →
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Original publication title: Identification of triple-negative and basal-like canine mammary carcinomas using four basal markers.
- Species:
- dog
Plain-English summary
A study found that 45 out of 241 dogs with mammary tumors had a type called triple-negative, which is known for a poor prognosis. These tumors did not express certain hormone receptors, making them more aggressive. Most of these triple-negative tumors also showed characteristics of a basal-like phenotype, meaning they had specific markers that could indicate a worse outcome. The researchers noted that while these tumors share some traits, more work is needed to fully understand the differences between them.
People also search for: dog mammary tumor treatment · triple-negative breast cancer in dogs · basal-like canine mammary carcinoma
Abstract
Molecular-based classification of canine mammary carcinomas (CMCs) has been a recent research focus. In human breast cancer, triple-negative and basal-like phenotypes are distinct molecular subgroups that are known for their poor prognosis, but these tumours are not yet well defined in the dog. The aim of this study was to determine whether CMCs include triple-negative and basal-like phenotypes by immunohistochemical assessment of expression of the oestrogen receptor (OR), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER2) and four basal markers, cytokeratin (CK) 14, CK5/6, p63 and the epidermal growth factor receptor (EGFR). In this study of 241 CMCs, 45 triple-negative tumours (OR(-), PR(-) and HER2(-)) were identified and this phenotype was associated with an unfavourable prognosis. In these tumours, the expression of CK14, CK5/6 and EGFR was related to clinicopathological parameters, while the expression of p63 was not relevant. The majority of the triple-negative tumours were of the basal-like phenotype, given that 75.6% of them expressed more than two basal markers. However, three of the basal markers were not uniformly expressed; therefore, the proportion of the basal-like phenotype was altered on the basis of the selection of the markers. Although both triple-negative and basal-like phenotypes are distinct entities in CMC, further study is needed to differentiate one from the other.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23079102/